Protein Details: Chloride channel protein ClC-Ka

Protein ID

ICDB_Pro_0591

Protein Name

Chloride channel protein ClC-Ka

Gene Name

CLCNKA

Organism

Homo sapiens (Human)

Length

687 amino acids

AlphaFoldDB

AF-P51800-F1-model_v4.pdb

Function

Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization; signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.

Sequence

MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLMTLGVLMALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTHTISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLVQALQAEPPSRAPGHQQCLQDILARGCPTEPVTLTLFSETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTNPPAPK

PDB Structures

2PFI

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 259; /ligand="Ca(2+)"; BINDING 261; /ligand="Ca(2+)"; BINDING 278; /ligand="Ca(2+)"; BINDING 281; /ligand="Ca(2+)";

Disease

Bartter Syndrome;Type 4B;Neonatal;With Sensorineural Deafness and Bartter Syndrome Type 4

Location

Expressed predominantly in the kidney. All nephron segments expressing BSND also express CLCNK proteins.

DOI ID

10.1073/pnas.91.15.6943; 10.1038/ng1285; 10.1038/nature04727; 10.1101/gr.2596504; 10.1038/35107099; 10.1136/jmg.2007.052944; 10.1085/jgp.201210878; 10.1016/j.str.2007.04.013; 10.1056/nejmoa032843

RefSeq

NP_001036169.1 [P51800-3]; NP_001244068.1 [P51800-2]; NP_004061.3 [P51800-1]